Company Name: |
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
Products Intro: |
Product Name:BRL 44408 CAS:118343-19-4 Package:100Mg,10Mg
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Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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Tel: |
821-50328103-801 18930552037 |
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3bsc@sina.com |
Products Intro: |
Product Name:BRL 44408 Maleate;2-[(4,5-Dihydro-1H-iMidazol-2-yl)Methyl]-2,3-dihydro-1-Methyl-1H-isoindoleMaleate CAS:118343-19-4 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Company Name: |
Chemsky (shanghai) International Co.,Ltd
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Tel: |
021-50135380 |
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shchemsky@sina.com |
Products Intro: |
Product Name:BRL 44408;2-[(4,5-Dihydro-1H-iMidazol-2-yl)Methyl]-2,3-dihydro-1-Methyl-1H-isoindole CAS:118343-19-4 Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| BRL 44408 MALEATE Basic information |
Product Name: | BRL 44408 MALEATE | Synonyms: | 2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE;2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE;BRL 44408 MALEATE;2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole;Alendronate sodium trihydrate,4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217;2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole;BRL 44408;2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt | CAS: | 118343-19-4 | MF: | C13H17N3 | MW: | 215.29 | EINECS: | | Product Categories: | Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Adrenoceptor | Mol File: | 118343-19-4.mol | ![BRL 44408 MALEATE Structure](CAS/GIF/118343-19-4.gif) |
| BRL 44408 MALEATE Chemical Properties |
Boiling point | 365.8±30.0 °C(Predicted) | density | 1.22±0.1 g/cm3(Predicted) | storage temp. | Desiccate at -20°C | solubility | H2O: ~26 mg/mL, soluble | form | solid | pka | 10.29±0.40(Predicted) | color | off-white |
| BRL 44408 MALEATE Usage And Synthesis |
Uses | Selective a2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration | Uses | BRL 44408 Maleate was used to study for norepinephrine reuptake modulators for preventing and treating vasomotor symptoms. | Uses | Selective α2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration. | Biological Activity | Selective α 2A -adrenoceptor antagonist (K i = 1.7 nM and 144.5 nM at α 2A and α 2B -adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α 2 -Adrenoceptor Tocriset™ . | Biochem/physiol Actions | BRL 44408 maleate is a selective α2A-adrenoceptor antagonist. | references | [1]. meana jj, callado lf, pazos a, et al. the subtype-selective alpha 2-adrenoceptor antagonists brl 44408 and arc 239 also recognize 5-ht1a receptors in the rat brain. eur j pharmacol, 1996, 312(3): 385-388. [2]. owesson ca, seif i, mclaughlin dp, et al. different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-a knockout mice. eur j neurosci, 2003, 18(1): 34-42. [3]. dwyer jm, platt bj, rizzo sj, et al. preclinical characterization of brl 44408: antidepressant- and analgesic-like activity through selective alpha2a-adrenoceptor antagonism. int j neuropsychopharmacol, 2010, 13(9): 1193-1205. |
| BRL 44408 MALEATE Preparation Products And Raw materials |
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