菜油甾醇
中文名称 | 菜油甾醇 |
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中文同义词 | 菜油甾醇;(3Β,24R)-麦角甾-5-烯-3-醇;24[R]-麦角甾-5烯-3Β-醇;芸苔甾醇;CAMPESTEROL 菜油甾醇;菜油甾醇, 来源于油菜种子;菜油甾醇?, >98%;喜树酯 |
英文名称 | CAMPESTEROL |
英文同义词 | (24R)-5-Ergosten-3beta-ol;(24R)-Methylcholest-5-en-3beta-ol;24alpha-Methylcholesterol;DELTA5-24-Isoergosten-3beta-ol;Ergost-5-en-3beta-ol, (24R)-;Ergost-5-en-3-ol, (3beta,24R)-;ERGOST-5-EN-3-BETA-OL;ERGOST-5-EN-3B-OL |
CAS号 | 474-62-4 |
分子式 | C28H48O |
分子量 | 400.69 |
EINECS号 | 207-484-4 |
植物来源 | 大豆 |
相关类别 | 标准品;对照品;中药对照品;植物提取物;合成;分析试剂标准品;生化试剂-碳水化合物类;类胡萝卜素;对照品-中药对照品;标准品 -中药标准品;标准品,对照品;通用生化试剂-天然产物;chemical reagent;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Steroids;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
Mol文件 | 474-62-4.mol |
结构式 |
菜油甾醇 性质
熔点 | 156-160 °C |
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比旋光度 | D23 -33° (22.5 mg in 5 ml chloroform) |
沸点 | 463.29°C (rough estimate) |
密度 | 0.98±0.1 g/cm3 (20 ºC 760 Torr) |
折射率 | 1.5100 (estimate) |
储存条件 | -20°C |
溶解度 | 氯仿(微溶)、甲醇(微溶、超声处理) |
形态 | 结晶 |
酸度系数(pKa) | 15.03±0.70(Predicted) |
颜色 | 白色 |
Merck | 13,1736 |
BRN | 3216975 |
InChIKey | SGNBVLSWZMBQTH-ZRUUVFCLSA-N |
LogP | 9.972 (est) |
Human Endogenous Metabolite
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Campesterol shows a weak cytotoxicity in non-proliferating human umbilical vein endothelial cells (HUVECs). Within the non-cytotoxic concentration range, campesterol significantly inhibits the bFGF-induced proliferation and tube formation of HUVECs in a concentration-dependent manner, while it does not affect the motility of HUVECs. 50 μg/mL of campesterol decreases the cell viability up to about 56% of control(IC 50 of over 50 μg/mL).
Campesterol effectively disrupts the bFGF-induced neovascularization in chick chorioallantoic membrane (CAM) in vivo .
药理药效:降低胆固醇,抗癌等活性
酿酒酵母体内菜油甾醇生物合成途径
[2] 周玉杰. 高速逆流色谱法分离β-谷甾醇和菜油甾醇的研究[J]. 精细化工, 2002: 183-185.
[3] P. JAIN S. B. Isolation of Lupeol, Stigmasterol and Campesterol from Petroleum Ether Extract of Woody Stem of Wrightia tinctoria[J]. Asian Journal of Plant Sciences, 2010, 9 1: 163-167. DOI:10.3923/AJPS.2010.163.167.
[4] M A F RKKIL T A M. Plasma lathosterol and campesterol in detection of ileal dysfunction.[J]. Scandinavian Journal of Gastroenterology, 1988, 23 1: 19-25. DOI:10.3109/00365528809093841.
安全信息
危险品标志 | Xn,T |
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危险类别码 | 20/21/22-36/37/38-48/20/22-40-38-22 |
安全说明 | 26-36-45-36/37/39-23 |
危险品运输编号 | UN 1888 6.1/PG 3 |
WGK Germany | 3 |
海关编码 | 29061990 |
提供商 | 语言 |
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英文
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