5'-ATP-K2
| 中文名称 | 5'-ATP-K2 |
|---|---|
| 中文同义词 | 5'-三磷酸腺苷二钾盐;腺苷-5'-三磷酸二钾盐;二水合-5`-三磷酸腺苷二钾盐;腺苷三磷酸二钾盐;ATP(二钾) |
| 英文名称 | ADENOSINE 5'-TRIPHOSPHATE POTASSIUM SALT |
| 英文同义词 | 5'-ATP-K2;ATP POTASSIUM SALT;adenosine 5'-triphosphate dipotassium*from bacter;ADENOSINE 5'-TRIPHOSPHATE DIPOTASSIUMFRO M BACTERIA;Adenosine 5μ-triphosphate dihydrate dipotassium salt;ADENOSINE-5'-TRIPHOSPHATE DIPOTASSIUM SALT;ADENOSINE 5'-TRIPHOSPHATE POTASSIUM SALT;Adenosine 5′-triphosphate dipotassium salt dihydrate,5′-ATP-K2 |
| CAS号 | 42373-41-1 |
| 分子式 | C10H14K2N5O13P3 |
| 分子量 | 583.36 |
| EINECS号 | |
| 相关类别 | 核糖核苷酸 |
| Mol文件 | 42373-41-1.mol |
| 结构式 |  |
5'-ATP-K2 性质
| 储存条件 | −20°C |
|---|---|
| 溶解度 | H2O:50 mg/mL |
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP dipotassium 是免疫和炎症中重要的内源性信号分子。
ATP dipotassium (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.
ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.
ATP dipotassium promotes neutrophil chemotaxis in vitro.
ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.
ATP dipotassium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo.
| Animal Model: | Four-week-old Kunming mice (18-22 g) |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection, before bacterial ( E. coli ) challenge |
| Result: | Protected mice from bacterial infection. |
| 提供商 | 语言 |
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英文
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