α,α-Difluorophenylacetic acid manufacturers
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| | α,α-Difluorophenylacetic acid Basic information |
| | α,α-Difluorophenylacetic acid Chemical Properties |
| Melting point | 65-75 °C | | Boiling point | 0°C | | density | 1.338±0.06 g/cm3(Predicted) | | Fp | 0°C | | storage temp. | Refrigerator, Under inert atmosphere | | solubility | Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly) | | form | Solid | | pka | 1.04±0.10(Predicted) | | color | White to Pale Yellow | | CAS DataBase Reference | 360-03-2(CAS DataBase Reference) |
| | α,α-Difluorophenylacetic acid Usage And Synthesis |
| Description | α,α-Difluorophenylacetic acid is a phenylacetic acid with two fluorides on the benzylic carbon. The inductive effect of the difluoromethyl group increases the acidity of α,α-difluorophenylacetic acid. α,α-difluorophenylacetic acid and 2-arylbenzoimidazoles could be used as reaction substrates to synthesise difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones through radical cascade cyclization[1]. | | Chemical Properties | white to light yellow crystal powde | | References | [1] Kaixia Sui, Yuting Leng* and Yangjie Wu*. “Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions.” ACS Omega 8 8 (2023): 7517–7528.
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| | α,α-Difluorophenylacetic acid Preparation Products And Raw materials |
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