PD 123319 二(三氟乙酸盐)
中文名称 | PD 123319 二(三氟乙酸盐) |
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中文同义词 | PD 123319 二(三氟乙酸盐);(S)-1-(4-(二甲氨基)-3-甲基苄基)-5-(2,2-二苯基乙酰基)-4,5,6,7-四氢-1H-咪唑并[4,5-C]吡啶-6-甲酸 2,2,2-三氟乙酸 (1:2) |
英文名称 | S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt |
英文同义词 | (S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate);PD 123319 bis(trifluoroacetate);PD 123,319 hydrate di(trifluoroacetate) salt;S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt;PD 123,319 di(trifluoroacetate) salt hydrate;S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate;PD 123319 (trifluoroacetate salt);PD123319; PD-123319; S-+-PD 123319 |
CAS号 | 136676-91-0 |
分子式 | C33H33F3N4O5 |
分子量 | 622.65 |
EINECS号 | |
相关类别 | |
Mol文件 | 136676-91-0.mol |
结构式 | ![]() |
PD 123319 二(三氟乙酸盐) 性质
储存条件 | 2-8°C |
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溶解度 | 在水中的溶解度为10mg/mL,澄清 |
形态 | 粉末 |
颜色 | 白色至黄色 |
水溶解性 | Soluble to 100 mM in water |
IC50: 34 nM (AT2 Receptor)
PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125 I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC 50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125 I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC 50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC 50 around 10 microM).