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| | S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Basic information |
| Product Name: | S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt | | Synonyms: | (S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate);PD 123319 bis(trifluoroacetate);PD 123,319 hydrate di(trifluoroacetate) salt;S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt;PD 123,319 di(trifluoroacetate) salt hydrate;S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate;PD 123319 (trifluoroacetate salt);PD123319; PD-123319; S-+-PD 123319 | | CAS: | 136676-91-0 | | MF: | C33H33F3N4O5 | | MW: | 622.65 | | EINECS: | | | Product Categories: | | | Mol File: | 136676-91-0.mol | ![S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Structure](CAS/GIF/136676-91-0.gif) |
| | S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble10mg/mL, clear | | form | powder | | color | White to yellow | | Water Solubility | Soluble to 100 mM in water |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Usage And Synthesis |
| Uses | PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:
- To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).
- To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).
- To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.
| | Biological Activity | PD 123319 ditrifluoroacetate is a potent and selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. | | in vitro | PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125 I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC 50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125 I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC 50 of 6.9 nM , and has a much lower affinity for DuP-753 (IC 50 around 10 microM). | | target | IC50: 34 nM (AT2 Receptor) | | storage | Store at -20°C |
| | S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Preparation Products And Raw materials |
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