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Hygromycin B

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Hygromycin B Basic information
Product Name:Hygromycin B
Synonyms:antihelmycin;hydromycinb;hygromix2.4;hygromix-8;hygrovetine;Hygromycin Solution;Hygromix;5-O-(2,3-O-(6-Amino-6-desoxyheptapyranosyliden)-beta-D-talopyranosyl)-desoxy-N'-methyl-D-streptamin
CAS:31282-04-9
MF:C20H37N3O13
MW:527.52
EINECS:250-545-5
Product Categories:antibiotic;Inhibitors
Mol File:31282-04-9.mol
Hygromycin B Structure
Hygromycin B Chemical Properties
Melting point 160-180°C
alpha D20 +20.2° (c = 1 in water)
Boiling point 608.13°C (rough estimate)
density 1.4252 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. 2-8°C
solubility H2O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.
form powder
pka7.1, 8.8(at 25℃)
color faintly brown to brown
PHpH (25g/l, 25℃ ) : 9.5~12.5
biological sourceStreptomyces hygroscopicus
Water Solubility Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents.
Merck 14,4852
BRN 6755837
Stability:Hygroscopic
EPA Substance Registry SystemHygromycin B (31282-04-9)
Safety Information
Hazard Codes T+,Xn,T
Risk Statements 26/27/28-41-42/43-40-36-23/24/25
Safety Statements 23-26-28-36/37/39-45-22-36-36/37
RIDADR UN 3462 6.1/PG 1
WGK Germany 3
RTECS WK2130000
19
HazardClass 6.1
PackingGroup I
HS Code 29419059
Toxicitymmo-esc 250 mg/L AACHAX 18,798,80
Hygromycin B Usage And Synthesis
DescriptionHygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 μg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph.
Chemical PropertiesWhite to off-white lyophilized powder
UsesHygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome
Usesantibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg
UsesHygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2.
UsesHygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib osome
ApplicationHygromycin B was found in the culture broth of Streptomyces hygroscopicus by Lilly Research Laboratories in 1953, as a mixture with hygromycin A. It showed activity against a variety of gram-positive and gram-negative bacteria as well as fungi. Hygromycin B has been used for therapy of helminthic infections in swine and poultry.
General DescriptionAmorphous solid or tan powder.
Air & Water ReactionsWater soluble.
Reactivity ProfileWeakly basic.
Fire HazardFlash point data for Hygromycin B are not available; however Hygromycin B is probably combustible.
Biochem/physiol ActionsMode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation. Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.
Safety ProfilePoison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox
storage+4°C
references[1] brodersen de, clemons wm jr, carter ap, et al. the structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin b on the 30s ribosomal subunit. cell, 2000, 103 (7): 1143-1154.
[2] ganoza mc, kiel mc. a ribosomal atpase is a target for hygromycin b inhibition on escherichia coli ribosomes. antimicrob agents chemother, 2001, 45 (10): 2813-2819.
Hygromycin B Preparation Products And Raw materials
Raw materialsStreptomyces hygroscopicus
Tag:Hygromycin B(31282-04-9) Related Product Information
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