- 6-Azauracil
-
- $0.00 / 25kg
-
2023-05-12
- CAS:461-89-2
- Min. Order: 10kg
- Purity: 98%
- Supply Ability: kg grade
- 6-Azauracil
-
- $1.00 / 1kg
-
2023-03-24
- CAS:461-89-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
- 6-Azauracil
-
- $0.00 / 1KG
-
2022-02-19
- CAS:461-89-2
- Min. Order: 1KG
- Purity: 98.7%
- Supply Ability: 100 tons
|
| 6-Azauracil Basic information |
| 6-Azauracil Chemical Properties |
Melting point | 274-275 °C(lit.) | Boiling point | 211.75°C (rough estimate) | density | 1.5988 (rough estimate) | refractive index | 1.4264 (estimate) | storage temp. | Store below +30°C. | form | Fine Crystalline Powder | pka | 7.78±0.20(Predicted) | color | White to light yellow | Water Solubility | Partly soluble in water, ethanol, DMSO, and 1 M NH4OH (50 mg/ml). | BRN | 116472 | InChI | InChI=1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8) | InChIKey | SSPYSWLZOPCOLO-UHFFFAOYSA-N | SMILES | N1=CC(=O)NC(=O)N1 | CAS DataBase Reference | 461-89-2(CAS DataBase Reference) | NIST Chemistry Reference | 1,2,4-Triazine-3,5(2H,4H)-dione(461-89-2) | EPA Substance Registry System | 1,2,4-Triazine-3,5(2H,4H)-dione (461-89-2) |
| 6-Azauracil Usage And Synthesis |
Chemical Properties | white to light yellow fine crystalline powder | Uses | 6-Azauracil (6-AU) is used as a growth inhibitor of various microorganisms via depletion of intracellular GTP and UTP nucleotide pools. 6-Azauracil has been widely used in investigations on modulation of transcription, especially in yeast models. | Definition | ChEBI: 6-azauracil is a 1,2,4-triazine compound having oxo-substituents at the 3- and 5-positions. It has a role as an antimetabolite. It is a member of 1,2,4-triazines and a nucleobase analogue. | Synthesis Reference(s) | The Journal of Organic Chemistry, 23, p. 1522, 1958 DOI: 10.1021/jo01104a033 | Biochem/physiol Actions | 6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP)?and uridine?triphosphate (UTP) nucleotide pools. | Safety Profile | Poison by
intraperitoneal route. Experimental
reproductive effects. Questionable
carcinogen with experimental tumorigenic
data. Mutation data reported. When heated
to decomposition it emits toxic fumes of
NOx. | Mode of action | 6-Azauracil is a growth inhibitor effective on a variety of microorganisms. It functions by depleting the intracellular GTP and UTP nucleotide supply. Mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways, exaggerate the growth defect of cells in the presence of 6 AU. |
| 6-Azauracil Preparation Products And Raw materials |
|