盐酸曲林菌素
| 中文名称 | 盐酸曲林菌素 |
|---|---|
| 中文同义词 | 盐酸曲林菌素;曲喹辛;化合物 T23476 |
| 英文名称 | HL 725 |
| 英文同义词 | 4,6-trimethylphenyl)imino)--2-((monohydrochloride;4h-pyrimido(6,1-a)isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl;HL 725;HL 725 HCL;2,3,6,7-TETRAHYDRO-9,10-DIMETHOXY-3-METHYL-2-[(2,4,6-TRIMETHYLPHENYL)IMINO]-4H-PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE HYDROCHLORIDE;9,10-DIMETHOXY-2-MESITYLIMINO-3-METHYL-2,3,6,7-TETRAHYDRO-4H-PYRIMIDO-(6,1-A)-ISOQUINOLIN-4-ONE, HCL;9,10-DIMETHOXY-2-MESITYLIMINO-3-METHYL-2,3,6,7-TETRAHYDRO-4H-PYRIMIDO-[6,1A]-ISOQUINOLIN-4-ONE HYDROCHLORIDE;TREQUINSIN HYDROCHLORIDE MINIMUM 98% |
| CAS号 | 78416-81-6 |
| 分子式 | C24H28ClN3O3 |
| 分子量 | 441.95 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 78416-81-6.mol |
| 结构式 |  |
盐酸曲林菌素 性质
| 熔点 | 210-211 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)) |
|---|---|
| 储存条件 | Desiccate at RT |
| 溶解度 | 二甲基亚砜：100mM；乙醇：100 mM |
| 形态 | 淡黄色固体 |
| 颜色 | 浅黄至黄色 |
Trequinsin hydrochloride (HL 725) 是高效的血小板 CAMP 磷酸二酯酶 (PDE)的抑制剂，IC50的0.25 nM。Trequinsin hydrochloride (HL 725) 是 ADP、胶原蛋白、凝血酶和肾上腺素在体外诱导的血小板聚集的极有效抑制剂。
Trequinsin hydrochloride exerts besides its cardiovascular and antihypertensive qualities very potent antiplatelet activities.
Trequinsin hydrochloride is an efficacious agonist of [Ca
2+
]
i
.
Cell Viability Assay
| Cell Line: | Samples from healthy volunteer research donors with normal sperm motility parameters in agreement with World Health Organization 2010 criteria. |
| Concentration: | 10 μM. |
| Incubation Time: | 20 min. |
| Result: | Caused a concentrationdependent increase in [Ca 2+ ] i (EC 50 = 6.4 μM [95% confidence interval (CI): 4.1-9.9 μM]). |
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | UW7727000 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-18740A | Trequinsin hydrochloride | 1 mg | 681元 | |
| 2024/04/30 | HY-18740A | 盐酸曲林菌素 Trequinsin hydrochloride | 78416-81-6 | 50mg | 9000元 |