- GS9620
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- $30.00 / 1kg
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2023-09-07
- CAS:1228585-88-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20 tons
- GS9620
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- $1.00 / 1KG
-
2019-08-08
- CAS:1228585-88-3
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
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| Product Name: | GS9620 | | Synonyms: | GS9620, >=98%;4-amino-2-butoxy-8-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one;4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one;4-Amino-2-butoxy-8-[3-(1-pyrrolidinylmethyl)benzyl]-7,8-dihydro-6(5H)-pteridinone;GS 9620;GS9620;GS-9620;4-Amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone | | CAS: | 1228585-88-3 | | MF: | C22H30N6O2 | | MW: | 410.51 | | EINECS: | | | Product Categories: | API | | Mol File: | 1228585-88-3.mol |  |
| | GS9620 Chemical Properties |
| density | 1.247±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (10 mg/ml) | | pka | 10.34±0.20(Predicted) | | form | solid | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | GS9620 Usage And Synthesis |
| Description | GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic infection and transiently activated HIV expressionex vivoin latently-infected peripheral blood mononuclear cells (PBMCs) from virally suppressed patients. Currently, GS-9620 is under clinical evaluation for treating chronic HBV infection and for reducing latent reservoirs in virally-suppressed HIV-infected patients. | | target | TLR-7 | | References | Lopatin, U, et al. "Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist." Antiviral Therapy18.3(2013):409-18.
Gane, E. J., et al. "The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection." Journal of Hepatology63.2(2015):320.
Lanford, Robert E., et al. "GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees." Gastroenterology 144.7(2013):1508. |
| | GS9620 Preparation Products And Raw materials |
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