10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
| 中文名称 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine |
|---|---|
| 中文同义词 | 化合物PSB-12062 |
| 英文名称 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine |
| 英文同义词 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine;PSB-12062;10-Tosyl-10H-phenoxazine;N-(p-Methylphenylsulfonyl)phenoxazine;10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]-;PSB-12062 >=98% (HPLC);P2X Receptor,Inhibitor,PSB12062,PSB 12062,PSB-12062,P2XRs,inhibit |
| CAS号 | 55476-47-6 |
| 分子式 | C19H15NO3S |
| 分子量 | 337.39 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 55476-47-6.mol |
| 结构式 | ![10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine 结构式](CAS/GIF/55476-47-6.gif) |
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：可溶，2mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
PSB-12062是有效，选择性的 P2X4 拮抗剂，对人类 P2X4 的 IC50 值为1.38 μM。
IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)
PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 5mg | 600元 |
| 2024/08/19 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 10mM * 1mLin DMSO | 660元 |