盐酸仑氨西林
| 中文名称 | 盐酸仑氨西林 |
|---|---|
| 中文同义词 | 化合物 T15734 |
| 英文名称 | LENAMPICILLIN HYDROCHLORIDE |
| 英文同义词 | (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-d-alpha-aminobenzylpenicillinatehyd;-2-carboxylicacid,hydrochloride;-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane;ampicillin,(5-methyl-2-oxo-1,3-dioxolen-4-yl)methylester,hydrochloride;carbonicacid,cyclic1-(hydroxymethyl)-2-methylethyleneester,esterwith6-(2;kb1585;kbt1585;kbt-1585 |
| CAS号 | 80734-02-7 |
| 分子式 | C21H23N3O7S |
| 分子量 | 461.49 |
| EINECS号 | |
| 相关类别 | 原料药;Amines;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol文件 | 80734-02-7.mol |
| 结构式 |  |
盐酸仑氨西林 性质
| 熔点 | 145° (dec) |
|---|---|
| 储存条件 | Store at -20°C, sealed storage, away from moisture and light |
| 溶解度 | DMSO:100.0(最大浓度 mg/mL);200.82(最大浓度 mM) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Lenampicillin hydrochloride (KBT 1585 hydrochloride) 是氨苄西林的口服前药，是一种有效的-内酰胺类抗菌(beta-lactam antibacterial) 剂，可抑制细菌的青霉素结合蛋白(转肽酶)。与氨苄西林相比，Lenampicillin 有改善吸收、减少副作用的作用，并应用于化脓性皮肤软组织感染的研究。
IC50: bacterial penicillin-binding proteins (transpeptidase)
Lenampicillin hydrochloride (KBT-1585) (oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis.Lenampicillin hydrochloride (LAPC) are identified for it main metabolites in rat and dogs. The main metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver.
安全信息
| 毒性 | LD50 in male, female rats, male, female mice (mg/kg): approx 10000, approx 10000, 8294, 8492 orally; 4362, 4471, 3576, 4284 s.c.; 876, 838, 711, 775 i.v.; in dogs (mg/kg): >300 orally (Ogino) |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100500 | 盐酸仑氨西林 Lenampicillin hydrochloride | 80734-02-7 | 5mg | 2800元 |
| 2024/01/25 | HY-100500 | 盐酸仑氨西林 Lenampicillin hydrochloride | 80734-02-7 | 10mg | 4800元 |