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| Product Name: | IMR-1A | | Synonyms: | IMR-1A;IMR1A;IMR 1A;IMR-1A;IMR-1A, >98%;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-;2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite | | CAS: | 331862-41-0 | | MF: | C13H11NO5S2 | | MW: | 325.36 | | EINECS: | | | Product Categories: | | | Mol File: | 331862-41-0.mol |  |
| | IMR-1A Chemical Properties |
| density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM) | | pka | 3.10±0.10(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | IMR-1A Usage And Synthesis |
| Biological Activity | IMR-1A is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. It has antitumor activity. | | in vivo | IMR-1A (2 mg/kg (iv) and 100 mg/kg (ip)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/ 2) of 2.22 h following a single iv administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration. | Animal Model: | Male C57 BL/6 mice | | Dosage: | 2 mg/kg (iv) and 100 mg/kg (ip) | < td class="col1 fwb"> Administration: | Iv and ip | | Result: | Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single iv administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration. | | | target | | Target | Value | Notch
(Cell-free assay) | 0.5 μM | Notch
(Cell-free assay) | 2.9 μM(Kd) | < /table>
| | IMR-1A Preparation Products And Raw materials |
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Tag:IMR-1A(331862-41-0)
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