331862-41-0
| 中文名称 | 331862-41-0 |
|---|---|
| 中文同义词 | NOTCH抑制剂(IMR-1A);化合物IMR-1A;2-(2-甲氧基-4-((4-氧代-2-硫代噻唑烷-5-亚基)甲基)苯氧基)乙酸 |
| 英文名称 | IMR-1A |
| 英文同义词 | IMR-1A;IMR1A;IMR 1A;IMR-1A;IMR-1A, >98%;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-;2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite |
| CAS号 | 331862-41-0 |
| 分子式 | C13H11NO5S2 |
| 分子量 | 325.36 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 331862-41-0.mol |
| 结构式 |  |
331862-41-0 性质
| 密度 | 1.55±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | DMSO:4.0(最大浓度 mg/mL);12.29(最大浓度 mM) 水:1.0(最大浓度 mg/mL);3.07(最大浓度 mM) |
| 酸度系数(pKa) | 3.10±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
IMR-1A 是IMR-1的酸性代谢产物，是一种 Notch 的有效的抑制剂，IC50值为0.5 μM，Kd值为2.9 μM。IMR-1A 具有抗肿瘤活性。
| Target | Value |
|
Notch
(Cell-free assay) | 0.5 μM |
|
Notch
(Cell-free assay) | 2.9 μM(Kd) |
IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.
| Animal Model: | Male C57 BL/6 mice |
| Dosage: | 2 mg/kg (i.v.) and 100 mg/kg (i.p) |
| Administration: | I.v. and i.p. |
| Result: | Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100431A | IMR-1A | 1 mg | 1200元 | |
| 2024/04/30 | HY-100431A | 331862-41-0 IMR-1A | 331862-41-0 | 5mg | 3000元 |