LY-3177833 manufacturers
- LY3177833
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- $1.00 / 1KG
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2020-01-02
- CAS:1627696-51-8
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
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| | LY-3177833 Basic information |
| Product Name: | LY-3177833 | | Synonyms: | LY-3177833;(R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)isoindolin-1-one;LY 3177833;LY-3177833;CS-2783;1H-Isoindol-1-one, 3-(5-fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-, (3R)-;LY3177833,CDK,Cyclin dependent kinase,Inhibitor,inhibit,LY 3177833 | | CAS: | 1627696-51-8 | | MF: | C16H12FN5O | | MW: | 309.3 | | EINECS: | | | Product Categories: | | | Mol File: | 1627696-51-8.mol |  |
| | LY-3177833 Chemical Properties |
| Boiling point | 660.7±55.0 °C(Predicted) | | density | 1.398±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:30.0(Max Conc. mg/mL);96.99(Max Conc. mM) | | form | A crystalline solid | | pka | 11.67±0.40(Predicted) | | color | White to off-white |
| | LY-3177833 Usage And Synthesis |
| Description | LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC50 = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day. |
| | LY-3177833 Preparation Products And Raw materials |
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