SPACE peptide
中文名称 | SPACE peptide |
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中文同义词 | SPACE肽;H-ALA-CYS-THR-GLY-SER-THR-GLN-HIS-GLN-CYS-GLY-OH(DISULFIDE BRIDGE:CYS2-CYS10);皮肤穿透肽SPACE PEPTIDE |
英文名称 | SPACE peptide |
英文同义词 | SPACE peptide;SPACE peptide,AC-TGSTQHQ-CG,Disulfide Bridge 2–10 |
CAS号 | 1621717-95-0 |
分子式 | C40H63N15O17S2 |
分子量 | 1090.15 |
EINECS号 | |
相关类别 | 多肽-客户肽;环肽 |
Mol文件 | Mol File |
结构式 |
SPACE peptide 性质
沸点 | 1870.9±65.0 °C(Predicted) |
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密度 | 1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) |
酸度系数(pKa) | 3.57±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
SPACE peptide, when conjugates to cargoes such as small molecules and proteins, is able to facilitate their penetration across the stratum corneum into epidermis and dermis.
SPACE peptide also exhibits increased penetration into various cells including keratinocytes, fibroblasts, and endothelial cells, likely through a macropinocytosis pathway.
SPACE peptide enhances Cyclosporine A skin penetration, via a transcellular pathway, enhancing its partitioning into keratin-rich corneocytes through concurrent binding of SPACE with keratin and Cyclosporine A.