- CEP-40783
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- $1.00 / 1KG
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2019-12-25
- CAS:1437321-24-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: G/KG/T
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| | CEP-40783 Basic information |
| Product Name: | CEP-40783 | | Synonyms: | CEP-40783;CEP-40783(RXDX-106);3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid [4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]amide;RXDX-106;CEP 40783; CEP40783; RXDX-106;RXDX-106(CEP-40783);CS-2528;5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo- | | CAS: | 1437321-24-8 | | MF: | C31H26F2N4O6 | | MW: | 588.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1437321-24-8.mol |  |
| | CEP-40783 Chemical Properties |
| density | 1.394±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:20.0(Max Conc. mg/mL);33.89(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.51(Max Conc. mM)
DMSO:6.04(Max Conc. mg/mL);10.26(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);3.4(Max Conc. mM) | | form | A crystalline solid | | pka | 10.42±0.70(Predicted) | | color | White to off-white |
| | CEP-40783 Usage And Synthesis |
| Uses | CEP-40783 is a potent, selective and orally potent inhibitor of axl and c-Met with IC50 values of 7nM and 12nM, respectively. | | Biological Activity | RXDX-106 (CEP-40783) is an orally available, potent, and selective inhibitor of TAM (TYRO3, AXL, MER)/Met (c-Met), with low levels in peptide phosphorylation assays. Nanomolar biochemical activity; slow dissociation rate (T1/2 >120 min) in in vitro kinase binding assays. | | in vitro | CEP-40783 inhibited TAM and c-MET phosphorylation, accompanied by a decrease in downstream MAPK and PI3K signaling and cellular activity. In TAM-expressing cells, sub-nanomolar concentrations of RXDX-106 completely inhibited cell proliferation and cell viability. | | in vivo | CEP-40783 inhibits tumors with activating TAM gene fusions and affects the TAM-expressing tumor microenvironment, resulting in an overall anticancer environment. | | target | | Target | Value | Axl
(Cell-free assay) | 7 nM | c-Met
(Cell-free assay) | 12 nM | Tyro3
(Cell-free assay) | 19 nM | MER
(Cell-free assay) | 29 nM | Tyro3
(Cell-free assay) | 29 nM |
| | CEP-40783 Preparation Products And Raw materials |
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Tag:CEP-40783(1437321-24-8)
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