促食素A
中文名称 | 促食素A |
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中文同义词 | 下视丘分泌素;增食欲素A/欲激素A抗体;阿立新A;促食素A;食欲素A(牛,人类,小鼠,大鼠);GLP-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-IIE-LEU-THR-LEU-NH2 (DISULFIDE BRIDGE: CYS6-CYS12, CYS7-CYS14);食欲素A;ANTI-OREXIN A ANTIBODY-增食欲素A/欲激素A抗体 |
英文名称 | Orexin A (bovine, human, mouse, rat) |
英文同义词 | OREXIN A (HUMAN, RAT, MOUSE);OREXIN-A (HUMAN) (RAT, MOUSE, BOVINE);OREXIN A (HUMAN, BOVINE, MOUSE, RAT);OREXIN A (HUMAN, BOVINE, RAT, MOUSE);PGLU-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2;HYPOCRETIN;OREXIN A (HUMAN, BOVINE, CANINE, MOUSE, OVINE, PORCINE, RAT);Hypocretin 1 |
CAS号 | 205640-90-0 |
分子式 | C152H243N47O44S4 |
分子量 | 3561.1 |
EINECS号 | |
相关类别 | 多肽;多肽-客户肽;定制多肽;试剂盒-细胞分析试剂盒;试剂盒-Elisa试剂盒;标准品;原料药;目录肽;Peptide;Orexin receptor;Peptide Receptors;hormones;医用原料;目录多肽;食品添加剂 |
Mol文件 | 205640-90-0.mol |
结构式 |
促食素A 性质
密度 | 1.53±0.1 g/cm3(Predicted) |
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储存条件 | -15°C |
溶解度 | 无菌条件下溶解度为 1 mg/ml |
形态 | 结晶固体 |
颜色 | 白色至米白色 |
水溶解性 | Soluble in water at 1mg/ml |
序列 | Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-IIE-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14) |
Orexin A human, rat, mouse has high affinity for OX1R, with 38 nM IC 50 and 34 nM EC 50 values in the the [Ca 2﹢ ]i transient assay.
Orexin A human, rat, mouse (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively.
Orexin A human, rat, mouse (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg.
Animal Model: | Female mice (mouse carrageenan-induced thermal hyperalgesia test) |
Dosage: | 3, 10 and 30 mg/kg |
Administration: | i.v.; 5 min pre-test |
Result: | Significantly increased the latency to response at 10 and 30 mg/kg. |
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
WGK Germany | 3 |
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海关编码 | 2937190000 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-106224 | 促食素A Orexin A (human, rat, mouse) | 205640-90-0 | 1mg | 4400元 |
2023/03/20 | HY-106224 | 促食素A Orexin A (human, rat, mouse) | 205640-90-0 | 5mg | 18000元 |