| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:PraMiverin Hydrochloride
CAS:14334-41-9
Package:100Mg,10Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:PraMiverin Hydrochloride;N-(1-Methylethyl)-4,4-diphenylcyclohexanaMine Hydrochloride; N-Isopropyl-4,4-diphenylcyclohexylaMine Hydrochloride; EMD 9806; HSp 2986; Monoverin; Sistalgin
CAS:14334-41-9
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:Pramiverin Hydrochloride
CAS:14334-41-9
Purity:NULL Package:100mg;10mg Remarks:NULL
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| Company Name: |
Shaanxi Xihua Chemical Industry Co., Ltd
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| Tel: |
17691182729 15529505138 |
| Email: |
1021@dideu.com |
| Products Intro: |
Product Name:4,4-diphenyl-N-propan-2-ylcyclohexan-1-amine,hydrochloride
CAS:14334-41-9
Purity:98 Package:25kg
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| | EMD-9806 Basic information |
| Product Name: | EMD-9806 | | Synonyms: | N-(1-Methylethyl)-4,4-diphenylcyclohexanaMine Hydrochloride;N-Isopropyl-4,4-diphenylcyclohexylaMine Hydrochloride;4,4-diphenyl-n-isopropylcyclohexylaminehydrochloride;SISTALGIN;PRAMIVERIN, HYDROCHLORIDE;N-(1-METHYLETHYL)-4,4-DIPHENYLCYCLOHEXANAMINE, HCL;4,4-diphenylcyclohexyl(isopropyl)ammonium chloride;4,4-diphenyl-n-isopropyl-cyclohexylaminhydrochloride | | CAS: | 14334-41-9 | | MF: | C21H28ClN | | MW: | 329.91 | | EINECS: | 238-284-5 | | Product Categories: | Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 14334-41-9.mol |  |
| | EMD-9806 Chemical Properties |
| Toxicity | LD50 (after 14 days) in mice, rats (mg/kg): 346, 623 orally; 25, 26 i.v. (Von Eberstein) |
| | EMD-9806 Usage And Synthesis |
| Originator | Sistalgin, Bracco, Italy,1974 | | Uses | A cyclohexanamine derivative with spasmolytic and analgesic activity. An effective anticholinergic agent. | | Manufacturing Process | 20 g 4,4-diphenyl-cyclohexen-(2)-one, 10 g isopropylamine, and 50 ml tetrahydrofuran are agitated for 10 hours in a bomb tube at 200°C. Subsequently, the reaction mixture is cooled, and the tetrahydrofuran and theexcess isopropylamine are distilled off. The remaining Schiff base is dissolved in methanol and after the addition of 2 g platinum oxide, the base is hydrogenated at normal pressure and room temperature until a quantity of hydrogen corresponding to 2 mols has been absorbed.
The mixture is filtered off from the catalyst, made acidic with dilute hydrochloric acid, and the methanol is removed under vacuum. The remaining aqueous solution is made alkaline with solution of sodium hydroxide and extracted with ether. After drying and concentrating the ether extract, there is obtained 17 g 1-isopropylamino-4,4-diphenyl-cyclohexane, boiling point 164°C to 165°C/0.05 mm. The hydrochloride melts at 230°C. | | Therapeutic Function | Spasmolytic |
| | EMD-9806 Preparation Products And Raw materials |
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