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Dinoprost tromethamine

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Products Intro: Product Name:Dinoprost tromethamine
CAS:38562-01-5
Purity:99% Package:1g,10g,100g,500g,1kg,25kg,100kg,500kg
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CAS:38562-01-5
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Products Intro: Product Name:Prostaglandin F2a tris salt,38562-01-5
CAS:38562-01-5
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CAS:38562-01-5
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Dinoprost tromethamine manufacturers

  • Dinoprost Tromethamine
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  • $0.00 / 1Kg/Bag
  • 2024-11-25
  • CAS:38562-01-5
  • Min. Order: 1Kg/Bag
  • Purity: EP9.0, GMP, DMF
  • Supply Ability: 20 tons
  • Dinoprost tromethamine
  • Dinoprost tromethamine pictures
  • $15.00 / 10gram
  • 2024-09-25
  • CAS:38562-01-5
  • Min. Order: 10gram
  • Purity: 99%
  • Supply Ability: 50000 kilograms

Related articles

  • Dinoprost Tromethamine
  • Dinoprost Tromethamine (Dinolytic, PGF2-alpha tham, Zinoprost, Prostin F2 alpha, Dinoprost Trometamol) is a synthetic analogue....
  • Jan 25,2022
Dinoprost tromethamine Basic information
Product Name:Dinoprost tromethamine
Synonyms:583e;7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacid,tromet;Tromethamine salt;PGF2α (Prostaglandin F2α);Dinoprost TroMethaMine USP;Dinorprost tromethamine;(E,Z)-(1R,2R,3R,5S)-7-[3,5-Dihydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]cyclopentyl]-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)@component of prostin F2 alpha, injectable;Dinoprost compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
CAS:38562-01-5
MF:C24H45NO8
MW:475.62
EINECS:254-002-3
Product Categories:APIs
Mol File:38562-01-5.mol
Dinoprost tromethamine Structure
Dinoprost tromethamine Chemical Properties
Melting point 100-101°
storage temp. -20°C
solubility H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.
form powder
color white
Merck 13,7970
BRN 4087514
Stability:Hygroscopic
InChIKeyIYGXEHDCSOYNKY-RZHHZEQLSA-N
Safety Information
Hazard Codes T
Risk Statements 60-22
Safety Statements 53-45
WGK Germany 3
RTECS UK8025000
8-10
HS Code 2937500000
MSDS Information
ProviderLanguage
SigmaAldrich English
Dinoprost tromethamine Usage And Synthesis
DescriptionDinoprost tromethamine is a synthetic analogue of prostaglandin. F2α is an autocrine hormone present in many mammalian tissues. It is used to cause luteolysis in the cow, sow and mare. It is given as a single injection by im or sc routes, the recommended dosage rate is 25 mg cow; 10 mg sow and 5 mg mare. It is rapidly absorbed from the injection site. It has an extremely short half life of only a few minutes, it is almost completely cleared following one or two passages through the liver and/or lungs.
Chemical PropertiesWhite Solid
OriginatorProstin F2A,Upjohn,UK,1972
UsesOne of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α. Oxytocic; abortifacient.
IndicationsDinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.
Definitiondinoprost tromethamine is a synthetic analogue of the naturally occurring prostaglandin F2 alpha. Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum.
Manufacturing ProcessA solution of tris(hydroxymethyl)aminomethane (1.645 grams) in 3.0 ml of water at 60°C is added with vigorous stirring to a solution of PGF2α, (5.00 grams) in 700 ml of acetonitrile which has just been
ought to its boiling point. The vessel which contained the aqueous amine solution is rinsed with three 0.66 ml portions of water, each rinsing being added with vigorous stirring to the acetonitrile solution. The mixture is then cooled to 25°C by immersion of the vessel in cool water. At the cloud point, the vessel wall (glass) below the liquid surface is scratched vigorously with a glass rod. The mixture is then maintained at 25°C for 24 hours.
The resulting crystals are collected by filtration under nitrogen, washed on the filter with 50 ml of acetonitrile, and then dried by passing nitrogen at 50°C through the filter cake for one hour. Drying is completed in an oven at 70°C for 8 hours to give 5.965 grams of the tris(hydroxymethyl)aminomethane salt of PGF2α in free flowing crystalline form; MP 100°-101°C.
Brand nameProstin F2 Alpha (Pharmacia & Upjohn).
Therapeutic FunctionSmooth muscle stimulant
Biochem/physiol ActionsProstaglandin F2α is induced by uterine-produced oxytocin and acts on the corpus luteum to cause luteolysis and inhibit progesterone production.
Safety ProfilePoison by intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Human reproductive effects by intervagmal route: terminates pregnancy, effects on fertility. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also other prostaglandin entries.
storageStore at -20°C
Dinoprost tromethamine Preparation Products And Raw materials
Raw materialsTris(hydroxymethyl)aminomethane-->PROSTAGLANDIN F2Α
Tag:Dinoprost tromethamine(38562-01-5) Related Product Information
Prostaglandin E2 Tricine BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE) Fosfomycin tromethamine BIS-Tris Sodium chloride Ketorolac tromethamine Dienogestrel Tris(hydroxymethyl)aminomethane Dexketoprofen trometamol Prostaglandin F2a TRISTEARIN PROSTAGLANDIN H2 15(S)-15-Methyl prostaglandin Carboprost tromethamine PROSTAGLANDIN G2 Candicidin 19(R)-HYDROXY PROSTAGLANDIN F2ALPHA