|
| 3-(4-FLUOROBENZOYL)PROPIONIC ACID Basic information |
| 3-(4-FLUOROBENZOYL)PROPIONIC ACID Chemical Properties |
Melting point | 100-102 °C (lit.) | Boiling point | 374.4±22.0 °C(Predicted) | density | 1.2441 (estimate) | storage temp. | Sealed in dry,Room Temperature | solubility | Chloroform (Slightly), Methanol (Slightly) | form | powder to crystal | pka | 4.50±0.17(Predicted) | color | White to Orange to Green | Water Solubility | Insoluble in water. | BRN | 958145 | CAS DataBase Reference | 366-77-8(CAS DataBase Reference) |
| 3-(4-FLUOROBENZOYL)PROPIONIC ACID Usage And Synthesis |
Chemical Properties | beige granular powder | Uses | 7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone. | Definition | ChEBI: 4-(4-Fluorophenyl)-4-oxobutanoic acid is an aromatic ketone. | General Description | 3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker. |
| 3-(4-FLUOROBENZOYL)PROPIONIC ACID Preparation Products And Raw materials |
|