化合物KL201
| 中文名称 | 化合物KL201 |
|---|---|
| 中文同义词 | 化合物KL201;2-溴-N-(5,6,7,8-四氢苯并[4,5]噻吩并[2,3-D]嘧啶-4-基)苯甲酰胺 |
| 英文名称 | 2-bromo-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide |
| 英文同义词 | 2-bromo-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide;Benzamide, 2-bromo-N-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-;KL201;KL201,CRY1,Inhibitor,Per2-dLuc,FBXL3,inhibit,clock,KL 201,circadian,cryptochrome,KL-201;2-Bromo-N-(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)benzamide |
| CAS号 | 302939-48-6 |
| 分子式 | C17H14BrN3OS |
| 分子量 | 388.28 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 302939-48-6.mol |
| 结构式 |  |
化合物KL201 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：250 mg/mL（643.87 mM） |
| 形态 | 固体 |
| 颜色 | 白色至黄色 |
KL201 是一种昼夜节律调制器，是一种同种型选择性隐花色素 1 (CRY1) 稳定剂。KL201 对 CRY2 没有稳定作用。KL201 延长了细胞和组织中的昼夜节律周期。
KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter
Per2-dLuc
. KL201 suppresses the intensity of
Per2-dLuc
reporter much more than that of
Bmal1-dLuc
, without affecting cellular viability.
KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3.
KL201 lengthened circadian period and suppressed the intensity of
Per2::Luc
knockin reporter in mouse lung primary explants.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-134194 | KL201 | 1 mg | 840元 | |
| 2024/08/19 | HY-134194 | KL201 | 302939-48-6 | 5mg | 1900元 |