FOXO4-DRI manufacturers
- FOXO4 /FOXO4-DRI
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- $0.00 / 1Box
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2024-05-29
- CAS:2460055-10-9
- Min. Order: 1Box
- Purity: 99
- Supply Ability: 20000BOX
- FOX04-DRI
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- $0.00 / 1g
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2024-05-18
- CAS:2460055-10-9
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 5kg
- FOXO4-DRI
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- $21.00 / 1box
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2024-05-15
- CAS:2460055-10-9
- Min. Order: 1box
- Purity: 99%
- Supply Ability: 10000box
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| | FOXO4-DRI Basic information |
| | FOXO4-DRI Chemical Properties |
| form | Solid | | color | White to off-white |
| | FOXO4-DRI Usage And Synthesis |
| Description |
FOXO4-DRI (Retro-Inverso) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. FOXO4-DRI has been shown in research to prevent normal FOXO4 binding to p53, thereby allowing for elimination of senescent cells, improved organ function, and younger tissue “biological age.” FOXO4-DRI impacts insulin signaling, cell cycle regulation, and oxidative stress signaling pathways. FOXO4-DRI is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in animal studies.
| | Biological Functions | FOXO4-DRI is a cell-permeable peptide comprising part of the p53-interaction domain of FOXO4. It can compete with endogenous FOXO4 for p53, thereby disrupting the FOXO4-p53 interaction. Disrupting the p53-FOXO4 interaction causes p53 to be excluded from the nucleus and directed to mitochondria for induction of apoptosis in senescent cells, ultimately eliminating senescent fibroblasts through triggering apoptosis[1-2]. FOXO4-DRI to be selective for ionizing radiation-induced senescent IMR90 cells and safe to normal cells. | | References |
[1] Yuzhao Huang. “Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes.” Frontiers in Bioengineering and Biotechnology (2021): 677576.
[2] Guihua Liu, Tingting Li, Xing Yang. “FOXO4-DRI ALLEVIATES AGE-RELATED TESTOSTERONE SECRETION INSUFFICIENCY VIA TARGETING SENESCENT LEYDIG CELLS IN AGED MICE.” Fertility and sterility (2020).
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| | FOXO4-DRI Preparation Products And Raw materials |
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