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N-NITROSO-L-PROLINE

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Products Intro: Product Name:N-NITROSO-L-PROLINE
CAS:7519-36-0
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CAS:7519-36-0
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CAS:7519-36-0
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Products Intro: Product Name:N-Nitroso L-Proline
CAS:7519-36-0

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  • 2024-08-15
  • CAS:7519-36-0
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  • Purity: 99.0%
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N-NITROSO-L-PROLINE Basic information
Product Name:N-NITROSO-L-PROLINE
Synonyms:1-Nitrosoproline;NPRO;L-Proline, 1-nitroso-;L-Proline, nitroso-;Nsc109545;N-NITROSO-L-PROLINE;1-nitroso-l-proline;nitrosoproline
CAS:7519-36-0
MF:C5H8N2O3
MW:144.13
EINECS:
Product Categories:Heterocycles;Amino Acids & Derivatives, Heterocycles;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives
Mol File:7519-36-0.mol
N-NITROSO-L-PROLINE Structure
N-NITROSO-L-PROLINE Chemical Properties
Melting point 108-109°C
Boiling point 262.71°C (rough estimate)
density 1.4054 (rough estimate)
refractive index 1.4472 (estimate)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
pka3.23±0.20(Predicted)
form Solid
color Pale Yellow to Brown
IARC3 (Vol. 17, Sup 7) 1987
Safety Information
ToxicityLD50 ipr-mus: 203 mg/kg JMCMAR 16,583,73
MSDS Information
N-NITROSO-L-PROLINE Usage And Synthesis
Chemical PropertiesColourless Plates
UsesA nitrosoamino acid with oncogenicity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg
UsesA nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg.
DefinitionChEBI: N-Nitrosoproline is a L-proline derivative.
Production MethodsThere is no indication that nitrosoproline was made commercially. It has been reported in cured meats (e.g., bacon) at concentrations of 340–440 μg/kg. Both higher and lower levels in several cured products have been reported by several authors.
Safety ProfilePoison by intraperitoneal route.Questionable carcinogen with experimental tumorigenicdata. Many nitroso compounds are carcinogens. Whenheated to decomposition it emits toxic fumes of NOx. Seealso NITROSO COMPOUNDS.
CarcinogenicityMice were given 0.1% NPRO in drinking water for 26 weeks, and no more lung adenomas were seen than in untreated controls at 38 weeks, showing a lack of carcinogenicity. In rats, higher doses (0.145%) in drinking water for 2 years showed no tumors that were not seen in untreated controls (174). IARC classified NPRO as not classifiable as to carcinogenicity to humans (Group 3).
N-NITROSO-L-PROLINE Preparation Products And Raw materials
Raw materialsN-(2,4-DINITROPHENYL)-L-PROLINE-->L-Proline-->2,4-Dinitrofluorobenzene
Tag:N-NITROSO-L-PROLINE(7519-36-0) Related Product Information
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