| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Sparsomycin
CAS:1404-64-4
Purity:>95%
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Sparsomycin
CAS:1404-64-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
- Sparsomycin
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- $473.00 / 1mg
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2024-10-28
- CAS:1404-64-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | SPARSOMYCIN Basic information |
| Product Name: | SPARSOMYCIN | | Synonyms: | Aids-012106;B 120121L19;nsc59729;sparsomycin;Sparsomycin from Streptomyces sparsogenes;(E)-N-[(S)-1-(Hydroxymethyl)-2-[[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxopyrimidine-5-yl)propenamide;U-19183;2-Propenamide, N-[(1S)-1-(hydroxymethyl)-2-[(R)-[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (2E)- | | CAS: | 1404-64-4 | | MF: | C13H19N3O5S2 | | MW: | 361.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1404-64-4.mol |  |
| | SPARSOMYCIN Chemical Properties |
| Melting point | 208-209° (dec) | | alpha | D25 +69° (c = 0.5 in water) | | density | 1.3893 (rough estimate) | | refractive index | 1.6390 (estimate) | | storage temp. | 2-8°C | | solubility | DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | | form | A solid | | pka | 8.67 in water, 9.05 in 40% ethanol | | color | White to off-white |
| Hazard Codes | T+ | | Risk Statements | 28 | | Safety Statements | 28-36/37-45 | | RIDADR | UN 2811 6.1/PG 2 | | RTECS | WG5850000 | | Toxicity | LD50 in dogs, rats, mice (mg/kg): 0.5-1.0, 2.25, 4.32 i.v. (Ottenheijm, 1986); LD50 i.p. in mice: 2.4 mg/kg (Owen) |
| | SPARSOMYCIN Usage And Synthesis |
| Description | Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities. It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi. Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site. It inhibits protein synthesis in bacteria, archaea, and eukaryotes. Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model. | | Uses | Research tool for studying protein biosynthesis. | | Uses | Sparsomycin is an antibiotic that binds to active site and exit tunnel hydrophobic crevices of peptidyltransferase center of Haloarcula marismortui large ribosomal subunit. |
| | SPARSOMYCIN Preparation Products And Raw materials |
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