GSK840
| 中文名称 | GSK840 |
|---|---|
| 中文同义词 | 化合物 T11501;化合物GSK840 |
| 英文名称 | GSK840 |
| 英文同义词 | GSK840;tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate;Inhibitor,RIP kinase,GSK 840,Receptor-interacting protein kinases,GSK840,inhibit,GSK-840,RIPK;tert-butyl2-(4-(5-(methylcarbamoyl)-1H-benzo[d]im;Benzeneacetic acid, 4-[5-[(methylamino)carbonyl]-1H-benzimidazol-1-yl]-, 1,1-dimethylethyl ester |
| CAS号 | 2361146-30-5 |
| 分子式 | C21H23N3O3 |
| 分子量 | 365.43 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2361146-30-5.mol |
| 结构式 |  |
GSK840 性质
| 密度 | 1.18±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 110 mg/mL，溶于 DMSO |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.16±0.46(Predicted) |
| 颜色 | 浅黄至黄色 |
GSK840 (GSK'840) 是一种受体相互作用蛋白激酶 3 (RIP3 或 RIPK3) 抑制剂，高亲和力结合 RIP3 激酶结构域，IC50 值为 0.9 nM，并抑制激酶活性，IC50 值为 0.3 nM。
IC50: 0.3 nM (RIP3)
GSK840 (GSK'840) (0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in a concentration-dependent manner.
GSK840 binds the kinase domain and inhibits kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli than can be achieved with RIP1 kinase inhibitors.
Cell Viability Assay
| Cell Line: | Human HT-29 cells (TNF 10 ng/ml + zVAD-fmk 20 μM + SMAC007 100 nM) |
| Concentration: | 0.01-3 μM |
| Incubation Time: | 24 hours |
| Result: | Blocked TNF-induced necroptosis in a concentration-dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-104021 | GSK840 GSK840 | 2361146-30-5 | 5mg | 720元 |
| 2024/08/19 | HY-104021 | GSK840 GSK840 | 2361146-30-5 | 10mM * 1mLin DMSO | 792元 |