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| | UBCS039 Basic information |
| Product Name: | UBCS039 | | Synonyms: | UBCS039;Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-;4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline;Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039 | | CAS: | 358721-70-7 | | MF: | C16H13N3 | | MW: | 247.29 | | EINECS: | | | Product Categories: | | | Mol File: | 358721-70-7.mol |  |
| | UBCS039 Chemical Properties |
| Boiling point | 453.9±45.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO : 125 mg/mL (505.48 mM) | | pka | 4.66±0.12(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | UBCS039 Usage And Synthesis |
| Biological Activity | UBCS039, the first synthetic SIRT6 activator with EC50 of 38 μM, induces time-dependent activation of autophagy in multiple human tumor cell lines. | | in vitro |
UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. It leads to autophagosome accumulation in human cancer cells.UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.
Western Blot Analysis
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Cell Line:
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Human H1299 cells.
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Concentration:
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75 μM.
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Incubation Time:
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48 and 72 hours.
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Result:
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Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.
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Cell Proliferation Assay
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Cell Line:
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Human H1299 cells.
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Concentration:
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100 μM.
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Incubation Time:
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48 and 72 hours.
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Result:
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Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.
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| | target | | Target | Value | SIRT6
(Cell-free assay) | 38 μM(EC50) |
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| | UBCS039 Preparation Products And Raw materials |
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