UBCS039
| 中文名称 | UBCS039 |
|---|---|
| 中文同义词 | 4-(吡啶-3-基)-4,5-二氢吡咯并[1,2-A]喹喔啉;化合物UBCS039 |
| 英文名称 | UBCS039 |
| 英文同义词 | UBCS039;Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-;4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline;Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039 |
| CAS号 | 358721-70-7 |
| 分子式 | C16H13N3 |
| 分子量 | 247.29 |
| EINECS号 | |
| 相关类别 | 有机化学;对照品 |
| Mol文件 | 358721-70-7.mol |
| 结构式 |  |
UBCS039 性质
| 沸点 | 453.9±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：125 mg/ml（505.48 mM） |
| 酸度系数(pKa) | 4.66±0.12(Predicted) |
UBCS039是第一个合成的SIRT6激活剂，EC50为38 μM，在多种人类肿瘤细胞系中均可诱导自噬的时间依赖性激活。
| Target | Value |
|
SIRT6
(Cell-free assay) | 38 μM(EC50) |
UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells.
UBCS039 leads to autophagosome accumulation in human cancer cells.
UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.
Western Blot Analysis
| Cell Line: | Human H1299 cells. |
| Concentration: | 75 μM. |
| Incubation Time: | 48 and 72 hours. |
| Result: | Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. |
Western Blot Analysis
| Cell Line: | Human H1299 cells. |
| Concentration: | 75 μM. |
| Incubation Time: | 48 and 72 hours. |
| Result: | Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. |
Cell Proliferation Assay
| Cell Line: | Human H1299 cells. |
| Concentration: | 100 μM. |
| Incubation Time: | 48 and 72 hours. |
| Result: | Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-115453 | UBCS039 | 1 mg | 685元 | |
| 2024/04/30 | S8909 | UBCS039 | 358721-70-7 | 10mM (1mL in DMSO) | 1777.23元 |