UBCS039
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- CAS号:
- 358721-70-7
- 英文名:
- UBCS039
- 英文别名:
- UBCS039;4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline;Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-;Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039
- 中文名:
- UBCS039
- 中文别名:
- 化合物UBCS039;4-(吡啶-3-基)-4,5-二氢吡咯并[1,2-A]喹喔啉
- CBNumber:
- CB95419868
- 分子式:
- C16H13N3
- 分子量:
- 247.29
- MOL File:
- 358721-70-7.mol
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UBCS039化学性质
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沸点:
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453.9±45.0 °C(Predicted)
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密度:
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1.25±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO : 125 mg/mL (505.48 mM)
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酸度系数(pKa):
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4.66±0.12(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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UBCS039性质、用途与生产工艺
UBCS039是第一个合成的SIRT6激活剂，EC50为38 μM，在多种人类肿瘤细胞系中均可诱导自噬的时间依赖性激活。
| Target | Value |
SIRT6
(Cell-free assay)
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38 μM(EC50)
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UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells.
UBCS039 leads to autophagosome accumulation in human cancer cells.
UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.
Western Blot Analysis
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Cell Line:
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Human H1299 cells.
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Concentration:
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75 μM.
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Incubation Time:
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48 and 72 hours.
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Result:
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Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.
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Western Blot Analysis
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Cell Line:
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Human H1299 cells.
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Concentration:
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75 μM.
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Incubation Time:
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48 and 72 hours.
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Result:
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Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.
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Cell Proliferation Assay
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Cell Line:
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Human H1299 cells.
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Concentration:
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100 μM.
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Incubation Time:
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48 and 72 hours.
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Result:
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Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.
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UBCS039
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-115453 | UBCS039 | | 1 mg | 685元 |
| 2024/11/08 | HY-115453 | UBCS039
UBCS039 | 358721-70-7 | 5mg | 1662元 |
358721-70-7, UBCS039 相关搜索:
- 抑制剂
- 药靶配体
- 对照品
- 有机化学
- 化合物UBCS039
- 4-(吡啶-3-基)-4,5-二氢吡咯并[1,2-A]喹喔啉
- 358721-70-7
- Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039
- 4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline
- Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-
- UBCS039