ChemicalBook >> CAS DataBase List >>UBCS039
UBCS039
- CAS No.
- 358721-70-7
- Chemical Name:
- UBCS039
- Synonyms
- UBCS039;4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline;Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-;Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039
- CBNumber:
- CB95419868
- Molecular Formula:
- C16H13N3
- Molecular Weight:
- 247.29
- MDL Number:
- MFCD00206184
- MOL File:
- 358721-70-7.mol
Last updated:2024-07-02 08:55:42
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
UBCS039 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0086992 | UBCS039 98.13% | 358721-70-7 | 5mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-0086992 | UBCS039 98.13% | 358721-70-7 | 10mg | $280 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0009227 | UBCS-039 95.00% | 358721-70-7 | 5MG | $458.62 | 2021-12-16 | Buy |
| ChemScene | CS-0086992 | UBCS039 98.13% | 358721-70-7 | 25mg | $570 | 2021-12-16 | Buy |
| ChemScene | CS-0086992 | UBCS039 98.13% | 358721-70-7 | 50mg | $960 | 2021-12-16 | Buy |
UBCS039 Chemical Properties,Uses,Production
Biological Activity
UBCS039, the first synthetic SIRT6 activator with EC50 of 38 μM, induces time-dependent activation of autophagy in multiple human tumor cell lines.
in vitro
UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. It leads to autophagosome accumulation in human cancer cells.UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.
Western Blot Analysis
| Cell Line: | Human H1299 cells. |
| Concentration: | 75 μM. |
| Incubation Time: | 48 and 72 hours. |
| Result: | Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. |
Cell Proliferation Assay
| Cell Line: | Human H1299 cells. |
| Concentration: | 100 μM. |
| Incubation Time: | 48 and 72 hours. |
| Result: | Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines. |
target
| Target | Value |
| SIRT6 (Cell-free assay) | 38 μM(EC50) |
UBCS039 Preparation Products And Raw materials
Raw materials
Preparation Products
UBCS039 Suppliers
Global( 45)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4197 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3717 | 55 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2989 | 58 |
UBCS039
Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-
4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline
Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039
358721-70-7