| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:Pomalidomide-PEG1-C2-N3
CAS:2271036-44-1
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
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| Company Name: |
Jilin Province Woda Biotechnology Co., Ltd.
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| Tel: |
13504435624 |
| Email: |
1927928688@qq.com |
| Products Intro: |
Product Name:1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS:2271036-44-1
Purity:98% 纯度 Package:1克;5克;100克
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| Company Name: |
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
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| Tel: |
025-86755008 17751752005 |
| Email: |
hszhang@bestfluorodrug.com |
| Products Intro: |
Product Name:4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2271036-44-1
Purity:95%+ Package:1g;5g;10g,25g
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| | E3 ligase Ligand-Linker Conjugates 50 Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 50 | | Synonyms: | E3 ligase Ligand-Linker Conjugates 50;Cereblon Ligand-Linker Conjugates 13;Pomalidomide-PEG1-C2-N3;4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;Poma-PEG1-N3;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- | | CAS: | 2271036-44-1 | | MF: | C17H18N6O5 | | MW: | 386.37 | | EINECS: | | | Product Categories: | | | Mol File: | 2271036-44-1.mol |  |
| | E3 ligase Ligand-Linker Conjugates 50 Chemical Properties |
| storage temp. | -20°C, stored under nitrogen | | form | Solid | | color | Light yellow to yellow |
| | E3 ligase Ligand-Linker Conjugates 50 Usage And Synthesis |
| Biological Activity | Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1]. | | storage | Store at -20°C | | References | [1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2. |
| | E3 ligase Ligand-Linker Conjugates 50 Preparation Products And Raw materials |
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