E3 ligase Ligand-Linker Conjugates 7 Free Base manufacturers
- (S,R,S)-AHPC-PEG4-NH2
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- $0.00 / 100mg
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2024-04-02
- CAS:2010159-57-4
- Min. Order: 100mg
- Purity: >98.00%
- Supply Ability: 100mg
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| | E3 ligase Ligand-Linker Conjugates 7 Free Base Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 7 Free Base | | Synonyms: | E3 ligase Ligand-Linker Conjugates 7 Free Base;VH032-PEG4-NH2;VHL Ligand-Linker Conjugates 4;PROTACs Related Compound 8;(S,R. S)-AHPC-PEG4-amine hydrochloride salt;L-Prolinamide, N-(14-amino-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7);(2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | | CAS: | 2010159-57-4 | | MF: | C32H49N5O8S | | MW: | 663.83 | | EINECS: | | | Product Categories: | | | Mol File: | 2010159-57-4.mol |  |
| | E3 ligase Ligand-Linker Conjugates 7 Free Base Chemical Properties |
| Boiling point | 901.7±65.0 °C(Predicted) | | density | 1.230±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in Water, DMSO, Methanol | | pka | 13.54±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | E3 ligase Ligand-Linker Conjugates 7 Free Base Usage And Synthesis |
| Description | (S, R, S)-AHPC-PEG4-amine is a PROTAC linker that incorporates an E3 ligase ligand with a PEG4 unit to empower drug research & discovery. The amine group is reactive with NHS ester or carboxylic acid. | | Uses | Protein degrader builiding block (S,R,S)-AHPC-PEG4-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| | E3 ligase Ligand-Linker Conjugates 7 Free Base Preparation Products And Raw materials |
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