| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride
CAS:1835705-61-7
Purity:(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride Package:50MG Remarks:905402-50MG
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| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:(S,R,S)-AHPC-(C3-PEG)2-C6-Cl
CAS:1835705-61-7
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
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| Company Name: |
Xi'an Confluore Biological Technology Co., Ltd.
|
| Tel: |
+86-156-80926068 +86-15680926068 |
| Email: |
1924344760@qq.com |
| Products Intro: |
Product Name:(S,R,S)-AHPC-6-5-6-Cl
CAS:1835705-61-7
Purity:95% HPLC Package:10MG;25MG;50MG;100MG;1G;5G Remarks:For customers outside China,please use the website:www.confluore.com
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E3 ligase Ligand-Linker Conjugates 11 manufacturers
- (S,R,S)-AHPC-6-5-6-Cl
-
- $0.00 / 1g
-
2024-04-02
- CAS:1835705-61-7
- Min. Order: 1g
- Purity: >95.00%
- Supply Ability: 1g
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| | E3 ligase Ligand-Linker Conjugates 11 Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 11 | | Synonyms: | E3 ligase Ligand-Linker Conjugates 11;(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride;VHL Ligand-Linker Conjugates 11;L-Prolinamide, N-[6-[[5-[(6-chlorohexyl)oxy]pentyl]oxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(S,R,S)-AHPC-6-5-6-Cl;(S,R,S)-AHPC-(C3-PEG)2-C6-C | | CAS: | 1835705-61-7 | | MF: | C39H61ClN4O6S | | MW: | 749.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1835705-61-7.mol |  |
| | E3 ligase Ligand-Linker Conjugates 11 Chemical Properties |
| Boiling point | 921.3±65.0 °C(Predicted) | | density | 1.152±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 14.08±0.40(Predicted) | | form | Solid | | color | Off-white to yellow |
| | E3 ligase Ligand-Linker Conjugates 11 Usage And Synthesis |
| Uses | Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| | E3 ligase Ligand-Linker Conjugates 11 Preparation Products And Raw materials |
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