- Tert-Butyl carbazate
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- $30.00 / 1kg
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2024-08-21
- CAS:870-46-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000kg
- tert-Butyl carbazate
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- $6.00 / 1KG
-
2024-08-13
- CAS:870-46-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20TONS
- Tert-Butyl Carbazate
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- $5.00 / 1KG
-
2024-08-13
- CAS:870-46-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000kg
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| tert-Butyl carbazate Basic information |
Product Name: | tert-Butyl carbazate | Synonyms: | TERT-BUTOXYCARBONYLHYDRAZINE;TERT-BOC-HYDRAZIDE;TERT-BUTYLOXYCARBAZATE;T-BUTOXYCARBONYL HYDRAZIDE;T-BUTYLOXYCARBONYL-HYDRAZIDE;tert-Butyl hydrazinocarboxylate;tert-Butylcarbazate,98+%;BOC-HYDRAZIDE 98% | CAS: | 870-46-2 | MF: | C5H12N2O2 | MW: | 132.16 | EINECS: | 212-795-3 | Product Categories: | bc0001;870-46-2 | Mol File: | 870-46-2.mol | ![tert-Butyl carbazate Structure](CAS/GIF/870-46-2.gif) |
| tert-Butyl carbazate Chemical Properties |
Melting point | 39-42 °C (lit.) | Boiling point | 63-65 °C/0.1 mmHg (lit.) | density | 1.02 | refractive index | 1.4496 (estimate) | Fp | 197 °F | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | solubility | Soluble in ethanol and methanol. | pka | 10.74±0.20(Predicted) | form | Crystalline Lumps | color | White to slightly yellow | Sensitive | Moisture Sensitive | BRN | 1756967 | InChIKey | DKACXUFSLUYRFU-UHFFFAOYSA-N | CAS DataBase Reference | 870-46-2(CAS DataBase Reference) | EPA Substance Registry System | Hydrazinecarboxylic acid, 1,1-dimethylethyl ester (870-46-2) |
| tert-Butyl carbazate Usage And Synthesis |
Chemical Properties | White to pale yellow lumps | Uses | Starting material for preparing BOC-azide, a reagent to introduce the BOC amino protection. | Uses | tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides. | Synthesis Reference(s) | Journal of the American Chemical Society, 82, p. 2725, 1960 DOI: 10.1021/ja01496a018 Chemical and Pharmaceutical Bulletin, 18, p. 217, 1970 DOI: 10.1248/cpb.18.217 | Purification Methods | Distil it in a Claisen flask with a water or oil bath at ca 80o. After a couple of drops have distilled, the carbazate is collected as an oil which solidifies to a snow white solid. It can be crystallised with 90% recovery from a 1:1 mixture of pet ether (b 30-60o) and pet ether (b 60-70o). [Carpino et al. Org Synth Coll Vol V 166 1973, Caprino et al. Org Synth 44 20 1964, Beilstein 3 IV 175.] |
| tert-Butyl carbazate Preparation Products And Raw materials |
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