1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE manufacturers
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| | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Basic information |
| Product Name: | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE | | Synonyms: | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE;RHC-80267;U-57908;N,N'-[1,6-Hexanediylbis(iminocarbonyloxy)]bis(cyclohexanimine);1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane;1,6-bis(cyclohexyloximinocarbonyl)hexane;1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908;Cyclohexanone, o,o'-(1,6-hexanediylbis(iminocarbonyl))dioxime | | CAS: | 83654-05-1 | | MF: | C20H34N4O4 | | MW: | 394.52 | | EINECS: | | | Product Categories: | Lipid signaling | | Mol File: | 83654-05-1.mol |  |
| | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Chemical Properties |
| Melting point | 118-121℃ | | density | 1.21±0.1 g/cm3(Predicted) | | RTECS | GW1485000 | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: 9 mg/mL | | form | solid | | pka | 13.81±0.46(Predicted) | | color | white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Usage And Synthesis |
| Description | RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1 | | Uses | RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid. | | Definition | ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound. | | General Description | Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α. | | Biological Activity | Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M). | | Biochem/physiol Actions | Product does not compete with ATP. | | storage | Store at +4°C | | References | 1) Southerland and Amin (1982), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; J. Biol. Chem., 257 14006
2) Rindlisbacher et al. (1990), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; J. Neurochem., 54 1247
3) Chandra Sekar et al. (1987), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Arch. Biochem. Biophys., 256 509
4) Levasseur et al. (1984), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; Prostaglandins, 27 673
5) Natarajan et al. (1988), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Biochem. Biophys. Res. Commun., 156 717 |
| | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Preparation Products And Raw materials |
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