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| | 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Basic information |
| Product Name: | 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE | | Synonyms: | 1,3,5(10)-ESTRATRIEN-3,16-ALPHA-DIOL-17-ONE;3,16ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE;(16R)-3,16α-Dihydroxy-1,3,5(10)-estratriene-17-one;16α-OHE1;3,16α-Dihydroxy-1,3,5(10)-estratrien-17-one;C05300;(16α)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one;Estra-1,3,5(10)-triene-3,16α-diol-17-one | | CAS: | 566-76-7 | | MF: | C18H22O3 | | MW: | 286.37 | | EINECS: | | | Product Categories: | Various Metabolites and Impurities;Steroids;Pharmaceuticals;Metabolites & Impurities;Intermediates & Fine Chemicals | | Mol File: | 566-76-7.mol | ![1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Structure](CAS/GIF/566-76-7.gif) |
| | 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Chemical Properties |
| Melting point | 209-211°C | | Boiling point | 493.2±45.0 °C(Predicted) | | density | 1.249±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) | | form | Solid | | pka | 10.23±0.60(Predicted) | | color | White to Light Beige |
| Hazard Codes | Xn | | Risk Statements | 40 | | Safety Statements | 22-36 | | WGK Germany | 3 |
| | 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Usage And Synthesis |
| Description | The naturally-occurring estrogens are estrone (E1, ), estradiol (E2, ), and estriol (E3, ). 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE1 are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive. | | Chemical Properties | Pale Pink Solid | | Uses | 16α-Hydroxy Estrone (Estriol EP Impurity H) is a major metabolite of Estradiol. | | Definition | ChEBI: The 16alpha-hydroxy derivative of estrone; a minor estrogen metabolite. |
| | 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Preparation Products And Raw materials |
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