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| NAPHTHOL AS-E PHOSPHATE Basic information |
Product Name: | NAPHTHOL AS-E PHOSPHATE | Synonyms: | NAPHTHOL AS-E PHOSPHATE;N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide;NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY;NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE;N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide;[3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate;[3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate;KD-501 | CAS: | 18228-17-6 | MF: | C17H13ClNO5P | MW: | 377.72 | EINECS: | 242-106-1 | Product Categories: | Substrates;API | Mol File: | 18228-17-6.mol | |
| NAPHTHOL AS-E PHOSPHATE Chemical Properties |
density | 1.567±0.06 g/cm3(Predicted) | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | solubility | DMSO: soluble | form | A crystalline solid | pka | 1.04±0.30(Predicted) | color | White to light yellow | BRN | 6664478 |
| NAPHTHOL AS-E PHOSPHATE Usage And Synthesis |
Biological Activity | Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM. | in vitro | Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons. | in vivo | Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex. | target | Target | Value | CREB () | table>
| NAPHTHOL AS-E PHOSPHATE Preparation Products And Raw materials |
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Tag:NAPHTHOL AS-E PHOSPHATE(18228-17-6)
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