四甲基若丹明甲酯酸铵
中文名称 | 四甲基若丹明甲酯酸铵 |
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中文同义词 | 四甲基罗丹明甲酯;四甲基罗丹明甲酯高氯酸盐;四甲基若丹明甲酯酸铵;四甲基若丹明甲酯高氯酸盐;罗丹明甲酯高氯酸盐;TMRM[四甲基罗丹明甲酯];3,6-双(二甲基氨基)-9-(2-(甲氧羰基)苯基)黄质高氯酸盐;3,6-双(二甲氨基)-9-(2-(甲氧基羰基)苯基)氧杂蒽鎓 高氯酸盐 |
英文名称 | TETRAMETHYLRHODAMINE METHYL ESTER PERCHLORATE |
英文同义词 | TMRM, PERCHLORATE;TETRAMETHYLRHODAMINE METHYL ESTER PERCHLORATE;Tetramethylrhodamin methylester perchlorate;XanthyliuM, 3,6-bis(diMethylaMino)-9-[2-(Methoxycarbonyl)phenyl]-, perchlorate (1:1);3,6-bis(diMethylaMino)-9-(2-(Methoxycarbonyl)phenyl)xanthyliuM perchlorate;T 668;TMRM [TetraMethylrhodaMine, Methyl ester, perchlorate];TMRM |
CAS号 | 115532-50-8 |
分子式 | C25H25ClN2O7 |
分子量 | 500.93 |
EINECS号 | |
相关类别 | 荧光探针,标记,颗粒和染色;Xanthene |
Mol文件 | 115532-50-8.mol |
结构式 |
四甲基若丹明甲酯酸铵 性质
熔点 | 274–276℃ |
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储存条件 | Sealed in dry,Room Temperature |
溶解度 | 可溶于DMSO |
形态 | 晶体 |
颜色 | 深绿色 |
最大波长(λmax) | 549 nm |
BRN | 7162165 |
生物领域应用 | Detecting mitochondrial membrane potential; apoptosis assays; multidrug resistance assays |
TMRM Perchlorate is a fluorescent probe (excitation, 530±21 nm; emission, 592±22 nm). The fluorescence signal in the presence of TMRM Perchlorate shows a slight decrease after the addition of glutamate, indicative of increased polarization of the mitochondrial inner membrane. In the presence of TMRM Perchlorate (2 μM) the coupled respiration with Complex I substrates or upon the addition of Complex II substrate is decreased by 27%. Exposure of hippocampal cultures to low concentrations of TMRM Perchlorate (50 to 500 nM) for 1 to 3 hours results in selective staining of mitochondria in both neurons and the underlying glial cells. Exposure of hippocampal cultures to high concentrations of TMRM Perchlorate (1 to 25 µM) stains mitochondria selectively and quickly, reaching a plateau after 5 to 10 min. Low concentrations of TMRM Perchlorate (50 to 200 nM) do not induce apoptosis, whereas higher concentrations (0.5 and 2.5 µM) enhance apoptosis (K D = 500 nM).
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | 46456 | 四甲基罗丹明甲酯高氯酸盐 Tetramethylrhodamine methyl ester perchlorate | 115532-50-8 | 25mg | 3577元 |
2024/08/19 | HY-D0984A | 四甲基若丹明甲酯酸铵 TMRM Perchlorate | 115532-50-8 | 5mg | 500元 |