| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:10-DEBC hydrochloride;10-[4'-(N,N-DiethylaMino)butyl]-2-chlorophenoxazinehydrochloride
CAS:201788-90-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:10-DEBC hydrochloride
CAS:201788-90-1
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | 10-DEBC HYDROCHLORIDE Basic information |
| Product Name: | 10-DEBC HYDROCHLORIDE | | Synonyms: | 10H-Phenoxazine-10-butanaMine,2-chloro-N,N-diethyl-;10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazinehydrochloride;10-DEBC HYDROCHLORIDE;aktX;CCG 206734;CCG-206734 | | CAS: | 201788-90-1 | | MF: | C20H25ClN2O | | MW: | 344.88 | | EINECS: | | | Product Categories: | | | Mol File: | 201788-90-1.mol |  |
| | 10-DEBC HYDROCHLORIDE Chemical Properties |
| Melting point | >178°C (dec.) | | Boiling point | 465.1±45.0 °C(Predicted) | | density | 1.134±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | form | White crystalline solid. | | pka | 10.46±0.25(Predicted) | | color | White to Off-White |
| | 10-DEBC HYDROCHLORIDE Usage And Synthesis |
| Uses | 10-DEBC Hydrochloride is an AKT inhibitor. Study shows that efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. | | Biological Activity | Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells. |
| | 10-DEBC HYDROCHLORIDE Preparation Products And Raw materials |
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