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| 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Basic information |
| 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Chemical Properties |
storage temp. | Desiccate at RT | solubility | DMSO: ≥10mg/mL | form | powder | color | off-white to light tan |
Hazard Codes | Xn | Risk Statements | 22-36/37/38 | Safety Statements | 26 | WGK Germany | 3 |
| 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Usage And Synthesis |
Uses | A highly selective histamine H4 receptor silent antagonist | Biological Activity | Highly selective histamine H 4 receptor silent antagonist; binds with high affinity to the human H 4 receptor (K i = 26 nM) and is > 540-fold selective over the H 3 receptor (K i = 14.1 μ M). In vitro, inhibits mast cell and eosinophil chemotaxis with IC 50 values of 138 and 530 nM respectively. Orally active in vivo . | storage | room temperature (desiccate) |
| 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Preparation Products And Raw materials |
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