雄酮
中文名称 | 雄酮 |
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中文同义词 | 雄酮;雄(甾)酮;雄甾酮,雄酮,雄性酮;3α-羟基-5α-雄甾烷-17-酮;(8R,9S,10S,13S,14S)-3-羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,14,15,16-十四氢环戊烷并[A]菲-17-酮;3-羟基雄烷-17-酮;雄酮 1G;表雄酮,雄甾酮,3Α-羟基-5Α-雄甾烷-17-酮 |
英文名称 | Androsterone |
英文同义词 | 3-alpha-hydroxy-17-androstanone;3alpha-Hydroxy-17-androstanone;3-alpha-hydroxy-5-alpha-androstan-17-on;3-Epihydroxyetioallocholan-17-one;3-hydroxy-,(3-alpha,5-alpha)-androstan-17-on;3-hydroxy-10,13-dimethylperhydrocyclopenta[a]phenanthren-17-one;ANDROSTERONE,98%(BULK;(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one |
CAS号 | 53-41-8 |
分子式 | C19H30O2 |
分子量 | 290.44 |
EINECS号 | 200-173-4 |
相关类别 | 内分泌与激素;细胞生物学;化工原料;甾体;临床检测标准物质;Steroids & Hormones - 13C & 2H;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 53-41-8.mol |
结构式 |
雄酮 性质
熔点 | 181-184 °C(lit.) |
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比旋光度 | 96 º (c=1, C2H5OH) |
沸点 | 372.52°C (rough estimate) |
密度 | 1.0320 (rough estimate) |
折射率 | 1.4709 (estimate) |
储存条件 | −20°C |
溶解度 | 乙腈:1mg/mL;乙醇:1mg/mL;甲醇:1mg/mL |
酸度系数(pKa) | 15.14±0.60(Predicted) |
水溶解性 | 11.5mg/L(23.5 ºC) |
Merck | 13,645 |
BRN | 2217626 |
CAS 数据库 | 53-41-8(CAS DataBase Reference) |
NIST化学物质信息 | Androsterone(53-41-8) |
EPA化学物质信息 | Androsterone (53-41-8) |
Human Endogenous Metabolite
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Androsterone activates both the mFXR-LBD and the hFXR-LBD, with Androsterone activating the mFXR-LBD more strongly than the hFXR-LBD. Furthermore, cotransfection studies with gal4-hFXR-LBD and SRC-1/VP16 expression plasmids demonstrate that Androsterone potentiates the interaction of SRC-1 with the hFXR-LBD. Several amino acid changes including H294S, S332V, R351H, and Y361F significantly reduce Androsterone activation. Androsterone (5α, 3α-A) (10 to 100 μM) also inhibits epileptiform discharges in a concentration-dependent fashion in the in vitro slice model.
Androsterone treatment results in a significant induction of small heterodimer partner (SHP), suggesting Androsterone may activate endogenous FXR. Intraperitoneal injection of Androsterone (5α, 3α-A) protects mice in a dose-dependent fashion from seizures in the following models (ED 50 , dose in mg/kg protecting 50% of animals): 6 Hz electrical stimulation (29.1), pentylenetetrazol (43.5), pilocarpine (105), 4-AP (215), and maximal electroshock (224).
安全信息
危险品标志 | Xi |
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危险类别码 | 36/37/38-43 |
安全说明 | 22-24/25-36/37-26 |
WGK Germany | 3 |
RTECS号 | BV8053000 |
F | 3-21 |
海关编码 | 29379000 |
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