平痉可宁
| 中文名称 | 平痉可宁 |
|---|---|
| 中文同义词 | 胺苄环已醚;苄环庚烷;苄环烷;哈里多;平痉可宁;化合物 T10502 |
| 英文名称 | bencyclane |
| 英文同义词 | N,N-dimethyl-3-[1-(phenylmethyl)cycloheptyl]oxypropan-1-amine;bencyclane;Benzcyclane;3-[1-(benzyl)cycloheptoxy]propyl-dimethyl-amine;N,N-dimethyl-3-[1-(phenylmethyl)cycloheptyl]oxy-propan-1-amine;Benzcyclan;1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)cycloheptyl]oxy]- |
| CAS号 | 2179-37-5 |
| 分子式 | C19H31NO |
| 分子量 | 289.46 |
| EINECS号 | 2185470 |
| 相关类别 | 医药原料;有机中间体 |
| Mol文件 | 2179-37-5.mol |
| 结构式 |  |
平痉可宁 性质
| 沸点 | bp3 146-156° |
|---|---|
| 密度 | 0.97±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | pKa 8.94±0.04(40%EtOH t=25.0) (Uncertain) |
| 形态 | 油状物 |
| 颜色 | 无色至浅黄 |
Benzcyclane (Bencyclane) 是血小板聚集抑制剂和有效研究各种外周循环障碍的血管扩张剂。
Benzcyclane, although capable of aggregating platelets by itself at very high concentrations, shows a striking inhibitory effect, over a wide range of concentrations, both on platelet aggregation induced by ADP, epinephrine or collagen and on platelet adhesiveness to glass or collagen. Clot retraction is also clearly inhibited. Benzcyclane induces use-dependent inhibition of Na channels in muscle, similarly as do class 1 antiarrhytnmic drugs. Inhibition was observed with both normal and cevadine-modified Na channels.