2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride
中文名称 | 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride |
---|---|
中文同义词 | 盐酸曲金刚胺;化合物 T13209L |
英文名称 | 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride |
英文同义词 | 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride;Einecs 255-434-5;Tromantadin hydrochlorid;Tromantadine HCl;Virumerz;Viru-merz;Viruserol |
CAS号 | 41544-24-5 |
分子式 | C16H28N2O2.ClH |
分子量 | 316.86666 |
EINECS号 | 2554345 |
相关类别 | |
Mol文件 | 41544-24-5.mol |
结构式 | ![]() |
2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride 性质
熔点 | 157-158° |
---|---|
形态 | 固体 |
颜色 | 白色至米白色 |
HSV-1
|
HSV-2
|
Treatment of the cells with 10 to 50μg of Tromantadine reduces HSV-induced cytopathic effect. Treatment with 100 to 500μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection.
安全信息
毒性 | LD50 orally in rats: 630 mg/kg; i.v. in mice: 71.0 mg/kg (Peteri, Sterner) |
---|