[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid
| 中文名称 | [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid |
|---|---|
| 中文同义词 | 化合物 T19430 |
| 英文名称 | [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid |
| 英文同义词 | [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid;[[6,7-Dichloro-2-methyl-2-phenyl-1-oxoindan-5-yl]oxy]acetic acid;Einecs 259-965-3;Acetic acid, 2-[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]- |
| CAS号 | 56049-88-8 |
| 分子式 | C18H14Cl2O4 |
| 分子量 | 365.21 |
| EINECS号 | 2599653 |
| 相关类别 | |
| Mol文件 | 56049-88-8.mol |
| 结构式 | ![[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid 结构式](CAS/GIF/56049-88-8.gif) |
[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid 性质
| 熔点 | 167-168 °C(Solv: acetic acid (64-19-7)) |
|---|---|
| 沸点 | 553.6±50.0 °C(Predicted) |
| 密度 | 1.422±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 2.80±0.10(Predicted) |
Indacrinone (MK196) 是一种研究性利尿剂，其在大鼠和狗中具有显着的盐水活性，并且在黑猩猩中具有尿酸和盐水活性。
As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the Indacrinone (MK-196)/1 ratio is 0.8 and 5 for the urine and feces, respectively. The urinary ratio of Indacrinone/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2).