1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Basic information

Product Name: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

Synonyms: 2-Acetyl-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;5-Fluoro-2-hydroxyphenyl(methyl) ketone;5'-Fluoro-2'-hydroxyacetophenone,97%;JRH-01009, 1-(5-Fluoro-2-hydroxyphenyl)ethanone, 97%;5’-fluoro-2’-hydroxy-acetophenon;Ethanone, 1-(5-fluoro-2-hydroxyphenyl)-;5'-FLUORO-2'-HYDROXYACETOPHENONE

CAS: 394-32-1

MF: C8H7FO2

MW: 154.14

EINECS: 206-893-5

Product Categories: Aryl Fluorinated Building Blocks;Building Blocks;C7 to C8;C7-C8;Chemical Synthesis;Fluorinated Building Blocks;Adehydes, Acetals & Ketones;Fluorine Compounds;Phenols;C7 to C8;Acetophenone series;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Alcohols and Derivatives;Carbonyl Compounds;Aromatic Acetophenones & Derivatives (substituted);ketone;(intermediate of nebivolol);Benzenes;Carbonyl Compounds;Ketones;1

Mol File: 394-32-1.mol

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Structure

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties

Melting point 56-58 °C(lit.)

Boiling point 65-66 °C8 mm Hg(lit.)

density 1.1850 (estimate)

Fp 65-66°C/8mm

storage temp. Inert atmosphere,Room Temperature

form powder to crystal

pka 10.17±0.18(Predicted)

color White to Gray to Brown

Water Solubility Soluble 0.68 G/L

BRN 2359087

CAS DataBase Reference 394-32-1(CAS DataBase Reference)

NIST Chemistry Reference 5-Fluoro-2-hydroxyacetophenone(394-32-1)

Safety Information

Hazard Codes Xi,Xn

Risk Statements 36/37/38-22

Safety Statements 26-37/39-36/37/39

WGK Germany 3

RTECS AM8502300

HazardClass IRRITANT

HS Code 29147000

MSDS Information

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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone English

ACROS English

SigmaAldrich English

ALFA English

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Usage And Synthesis

Chemical Properties light yellow to beige-brown crystals or

Uses 5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:

1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one

3-hydroxy and 3-methoxyflavones

3-hydroxy and 3-methoxy 2-styrylchromones

Definition ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.

Preparation Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).