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Postion:Product Catalog >API>Circulatory system drugs>Angina Pectoris Drugs>Isosorbide Dinitrate
Isosorbide Dinitrate
  • Isosorbide Dinitrate

Isosorbide Dinitrate NEW

Price $10
Package 1kg
Min. Order: 1kg
Supply Ability: 10 ton
Update Time: 2024-10-11

Product Details

Product Name: Isosorbide Dinitrate CAS No.: 87-33-2
Min. Order: 1kg Purity: 98%
Supply Ability: 10 ton Release date: 2024/10/11
Payment: Bank Transfer, TT Packaging: 25kg drums
Keywords 1 : Isosorbide Dinitrate supplier Keywords 2: Isosorbide Dinitrate manufacturer
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USP 99% Isosorbide Dinitrate Powder CAS 87-33-2


Product Description
Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.
Function

Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxid e (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.


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  • Since: 2021-12-10
  • Address: Qiaoxi District ,Shijiazhuang city, Hebei,Chicna
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