isosorbide dinitrate NEW
| Price | Get Latest Price | ||
| Package | 1g | 5g | 25g |
| Min. Order: | 1g |
| Supply Ability: | 20 tons |
| Update Time: | 2024-04-07 |
Product Details
| Product Name: isosorbide dinitrate | CAS No.: 87-33-2 |
| Min. Order: 1g | Purity: 99.9% |
| Supply Ability: 20 tons | Release date: 2024/04/07 |
Basic Information
CAS No:87-33-2
Molecular Formula:C6H8N2O8
Molecular Weight: 236.13
Appearance: Fine white crystal
isosorbide dinitrate Properties
Item | Specifications |
|---|---|
Appearance | Fine white crystal |
Purity/% | 99.9% |
| Density b(20℃)（kg/m3) | 1700 |
| Melting Point/℃ | 173 |
| Flashpoint/℃ | 186.6 |
| PSA | 128.5 |
| Refractive index | 1.538 |
| solubility | Soluble in chloroform, acetone, slightly soluble in ethanol, slightly soluble in water |
| Mechanical impurities | NO |
isosorbide dinitrate USES
The clinical application is mainly for the treatment of coronary heart disease; Prevention of angina; Treatment of persistent angina pectoris after myocardial infarction; In combination with digitalis and/or diuretics to treat chronic congestive heart failure; Treatment of pulmonary hypertension.
The main pharmacological effect of isosorbide nitrate (ISDN) is to relax vascular smooth muscle. ISDN is metabolized in the body to produce isosorbide mononitrate (ISMN), which releases nitric oxide (NO), which is the same as endothelial relaxation factor, activates guanylate cyclase, increases the cyclic guanylate (cGMP) in smooth muscle cells, thus relaxing vascular smooth muscle, dilating peripheral arteries and veins, and having a stronger effect on venous dilation. Venous dilation results in peripheral blood retention, reduced cardiac return, left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arterial dilation reduces peripheral vascular resistance, systolic arterial pressure and mean arterial pressure (afterload). Coronary artery dilation increases coronary perfusion volume. The overall effect is to reduce the oxygen consumption of the heart muscle, increase the oxygen supply, and relieve angina pectoris.
isosorbide dinitrate Packaging
Packing: 1g，5g，25g/Drum
Belonging to common goods
isosorbide dinitrate Storage
1. Stored in a cool dry place away from direct sunlight and water
2. Separated from oxidants and foodstuffs
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Q 1 : Do you have stock?
A: Yes, we have all our products in stock. Our annual output is 200 tons. No matter when you order, we will ship within 1 to 3 days.
Q 2 : What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
Q 3 : Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over
5years, in average.Strict quality control-comes form our sophisticated management system.Professional and warm sales team-since we
believe we can only win via our hard work in a competitive worldQuick response and excellent presale and after sale service-since
we believe our customers deserve all the best service.
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A: Of course. We don't chase excessive profits and always try tp give best offer. We are not pursuing short-term interests, but long-term cooperation. So we'll do our best to meet your request.
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Company Profile Introduction
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China- Since: 2023-10-24
- Address: Huangdao District, Qingdao City, Shandong Province (formerly Room 606-2, Building 1, No. 10, Beijing