Product Details
| Product Name:
FzM1 |
CAS No.:
1680196-54-6 |
| Purity:
99.89% |
Supply Ability:
10g |
| Release date:
2024/11/11 |
Product Introduction
Bioactivity
| 名称 | FzM1 |
| 描述 | FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway. |
| 体外活性 | FzM1 inhibited Gli activity less efficiently than TCF/LEF activity (log EC50 of −4.6 and −5.7, respectively). On the contrary, it did not modulate CRE activity (log EC50 > −4.0), indicating that it does not influence GPCRs linked to G proteins[2]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 65 mg/mL (180.34 mM), Sonication is recommended.
|
| 关键字 | FzM1 |
| 相关产品 | Urea | PRI-724 | Wnt pathway activator 1 | L-quebrachitol | MSAB | EMT inhibitor-1 | Wogonin | CHIR-99021 | XAV-939 | Nefopam hydrochloride | KY-05009 | Bisdemethoxycurcumin |
| 相关库 | 经典已知活性库 | 抗卵巢癌化合物库 | 抗癌细胞代谢库 | 神经保护化合物库 | 干细胞分化化合物库 | 已知活性化合物库 | 细胞骨架化合物库 | 神经元分化化合物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:852146-73-7
$64.00 / 1mg
-
CAS:21853-11-2
$45.00 / 1mg
-
CAS:186611-52-9
$64.00 / 5mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States