Ibuprofen NEW

Product Description:

Ibuprofen (Ibuprofen), also known as isobuprofen, is a non-steroidal anti-inflammatory analgesic. Its anti-inflammatory, analgesic and antipyretic effects are good, and the side effects are small. At present, it has been widely used in the world, becoming one of the world's best-selling over-the-counter drugs, and aspirin, paracetamol and listed as the three pillar products of antipyretic analgesics. In China, it is mainly used in pain relief, anti-rheumatic and other aspects, and the application of cold and fever is not too much, far lower than paracetamol and aspirin. There are as many as dozens of pharmaceutical enterprises in China that hold the approval number of ibuprofen preparations, but the vast majority of ibuprofen sales in the domestic market are occupied by the "Fenbeide" sustained-release capsules produced by the Sino-American SmithKline Company in Tianjin. Ibuprofen was discovered by Dr Stephen Adams (who later became a professor and was awarded an MBE) and his team, led by research specialist Colyn Burrows and chemist Dr JohnNicholson. The goal of the initial research was to create a "super aspirin" that could lead to an alternative treatment for rheumatoid arthritis that is as effective as aspirin but has fewer serious adverse effects. Other drugs, such as butazone, have a high risk of agranulocytosis; Corticosteroids, when used in doses slightly higher than commonly prescribed, carry a higher risk of adrenal depression and other adverse effects such as gastrointestinal ulcers. Adams decided to look for a drug with good gastrointestinal tolerability, a property that is particularly important for all current nonsteroidal anti-inflammatory drugs. Phenylacetate drugs have aroused interest. Although some of these drugs were found to be dangerous for ulcers in dog trials, Adams realized that this could be due to the longer half-life the drugs take to clear. One of the compounds in this class, ibuprofen, has a relatively short half-life of just two hours. Of the alternatives tested, though not the most effective, they are the safest. In 1964 ibuprofen emerged as the most promising alternative to aspirin.