![Imatinib Mesylate (STI571)](/ProductImageEN/2023-08/Large/bb859b82-a027-40bf-922a-8623168c7baf.jpg)
Imatinib Mesylate (STI571) NEW
Price | Get Latest Price |
Package | 1g |
Min. Order: | 1g |
Supply Ability: | 1kg |
Update Time: | 2024-03-12 |
Product Details
Product Name: Imatinib Mesylate (STI571) | CAS No.: 220127-57-1 |
Min. Order: 1g | Purity: 98% HPLC |
Supply Ability: 1kg | Release date: 2024/03/12 |
Imatinib mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to intracellular pockets located within tyrosine kinases (TKs), thereby inhibiting ATP binding and preventing phosphorylation and subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene and receptor TK encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of bcr-abl TK leads to decreased malignant cell proliferation and increased apoptosis in Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit hypertrophy in diseases overexpressing c-kit Cells and cell proliferation, such as in mastocytosis and gastrointestinal stromal tumors (GIST).
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- Since: 2014-09-09
- Address: No.28 Hua Long Road,Ji Nan City,China